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A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export
- Source :
- Cell host & microbe, vol 20, iss 5
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Nuclear mRNA export is highly regulated to ensure accurate cellular gene expression. Viral inhibition of cellular mRNA export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. We report that ORF10 of Kaposi's sarcoma associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome-wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3' untranslated regions (3' UTRs) of ORF10-targeted transcripts conferring sensitivity to export inhibition. The Rae1-ORF10 interaction is important for the virus to express viral genes and produce infectious virions. These results suggest that a nuclear DNA virus can selectively interfere with RNA export to restrict host gene expression for optimal replication.
- Subjects :
- 0301 basic medicine
Nucleocytoplasmic Transport Proteins
viruses
Messenger
Virus Replication
Nuclear Matrix-Associated Proteins
Models
ORF10
Gene expression
Protein biosynthesis
2.2 Factors relating to the physical environment
2.1 Biological and endogenous factors
Aetiology
late gene
Translation (biology)
Active Transport
Nup98
Infectious Diseases
mRNA nuclear export
Medical Microbiology
Herpesvirus 8, Human
Host-Pathogen Interactions
HIV/AIDS
Infection
Human
Protein Binding
Biotechnology
3′ UTR
Immunology
Active Transport, Cell Nucleus
KSHV
Biology
Models, Biological
Microbiology
Article
Virus
Cell Line
Viral Proteins
03 medical and health sciences
Rare Diseases
herpesvirus
Virology
Genetics
Animals
Humans
RNA, Messenger
Herpesvirus 8
Nuclear export signal
Cell Nucleus
Messenger RNA
Three prime untranslated region
RNA
Biological
Molecular biology
Emerging Infectious Diseases
030104 developmental biology
Gene Expression Regulation
Parasitology
Rae1
Subjects
Details
- ISSN :
- 19313128
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Cell Host & Microbe
- Accession number :
- edsair.doi.dedup.....5367f7ff166c1e4e25881454e0c77ddb