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Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade
- Source :
- Biochemical and biophysical research communications. 599
- Publication Year :
- 2021
-
Abstract
- Acute lung injury (ALI) is a significant cause of morbidity and mortality worldwide. To search for a new treatment for acute lung injury, we investigated the effect of escitalopram on lipopolysaccharide (LPS)-induced ALI. Our results showed that escitalopram inhibited salt-inducible kinase 2 (SIK2) activity (IC
- Subjects :
- Inflammation
Lipopolysaccharides
Male
Acute Lung Injury
Biophysics
Active Transport, Cell Nucleus
Drug Repositioning
NF-kappa B
Cell Biology
Protein Serine-Threonine Kinases
Biochemistry
Histone Deacetylases
Mice, Inbred C57BL
Mice
Escitalopram
RAW 264.7 Cells
Animals
Phosphorylation
Molecular Biology
Signal Transduction
Subjects
Details
- ISSN :
- 10902104
- Volume :
- 599
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....535b397da901c31949eb05928e1e3fe2