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HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study
- Source :
- Science progress. 104(3)
- Publication Year :
- 2021
-
Abstract
- This integrated bioinformatic study aimed to investigate potential prognostic candidates in hepatocellular carcinoma (HCC). In the GSE14520, GSE101685, and The Cancer Genome Atlas (TCGA) datasets, differentially expressed genes (DEGs) were identified and functional pathways of common DEGs were enriched. The least absolute shrinkage and selection operator (LASSO) model was used to screen the potential parameters associated with overall survival (OS) in HCC patients. Metabolic pathways were the most significantly enriched functional pathways of common DEGs in these three datasets. After LASSO model analysis, HMGCS2, UGP2, BCLC staging and TNM staging were screened as potential prognostic candidates for OS in HCC patients in GSE14520. HMGCS2 in the metabolic pathway was significantly downregulated in tumor tissues and peripheral blood mononuclear cells in HCC patients (all p 5 cm, multinodular, advanced tumor staging including BCLC, TNM and CLIP (all p
- Subjects :
- 0301 basic medicine
Hydroxymethylglutaryl-CoA Synthase
Multidisciplinary
Carcinoma, Hepatocellular
Gene Expression Profiling
Liver Neoplasms
Biology
medicine.disease
digestive system diseases
03 medical and health sciences
Metabolic pathway
030104 developmental biology
0302 clinical medicine
Lasso (statistics)
Ketone body metabolism
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer genome
Cancer research
Overall survival
medicine
Biomarkers, Tumor
Leukocytes, Mononuclear
Humans
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 20477163
- Volume :
- 104
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Science progress
- Accession number :
- edsair.doi.dedup.....5358cb0b42b9688feb39c294ed10e613