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Role of miRNALet-7and Its Major Targets in Prostate Cancer
- Source :
- BioMed Research International, BioMed Research International 2014 (2014), BioMed Research International, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specific antigen levels are chronically elevated in the absence of cancer. Due to the unsatisfying efficiency of available prostate cancer screening markers and the current treatment outcome of the aggressive hormone refractory prostate cancer, the evaluation of novel molecular markers and targets is considered an issue of high importance. MicroRNAs are relatively stable in body fluids orchestrating simultaneously the expression of many genes. These molecules are currently discussed to bear a greater diagnostic potential than protein-coding genes, being additionally promising therapeutic drugs and/or targets. Herein we review the potential impact of the microRNAlet-7family on prostate cancer and show how deregulation of several of its target genes could influence the cellular equilibrium in the prostate gland, promoting cancer development as they do in a variety of other human malignant neoplasias.
- Subjects :
- Male
cyclin D2
lcsh:Medicine
high mobility group A2 protein
Review Article
gene targeting
Prostate cancer
GSK-3
androgen receptor
tumor gene
high mobility group B1 protein
genetics
prostate tumor
microRNA
mitogen activated protein kinase
deregulation
oncogene c myc
gene expression regulation
General Medicine
prostate cancer
unclassified drug
Gene Expression Regulation, Neoplastic
immunoglobulin enhancer binding protein
Prostate cancer screening
Ras protein
interleukin 6
Biology
Models, Biological
General Biochemistry, Genetics and Molecular Biology
Antigen
medicine
Humans
ddc:610
human
Interleukin 6
nonhuman
General Immunology and Microbiology
lcsh:R
high mobility group A protein
Prostatic Neoplasms
Cancer
glycogen synthase kinase 3
biological model
medicine.disease
Androgen receptor
MicroRNAs
let 7 protein
Myc protein
Cancer research
biology.protein
Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
protein
metabolism
Genes, Neoplasm
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....535750b725671c149b51635a0530ba97