Back to Search
Start Over
Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease
- Source :
- Transplant Infectious Disease. 16:897-903
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Background Although the majority of post-transplant lymphoproliferative disorder (PTLD) cases are associated with Epstein–Barr virus (EBV), 20–42% of cases are EBV negative (EBV-N). The antigenic stimulus that drives EBV-N PTLD is unknown, but is likely heterogeneous. A common feature of PTLD, regardless of EBV status, is an abnormal polytypic lymphoplasmacytic infiltrate. Immunglobulin-G4 (IgG4) syndrome is also characterized by a polytypic lymphoplasmacytic infiltrate with a predominance of IgG4-positive (IgG4-P) plasma cells. Methods We investigated the possibility of an association between EBV-N PTLD and IgG4 syndrome. Of 33 evaluated PTLD cases, 9 (27%) were EBV-N. EBV-N PTLD cases showed longer transplantation-to-diagnosis times than EBV-positive cases. Results A single patient had a preceding benign duodenal biopsy with focally prominent IgG4-P plasma cells; however, no clinical data supported IgG4 syndrome, precluding an association between IgG4 syndrome and subsequent EBV-N PTLD in this patient. Conclusion As none of 29 evaluable cases of PTLD (including all 9 EBV-N cases) were associated with an increase in IgG4-P plasma cells, IgG4 syndrome does not appear to play a role in the etiology of EBV-N PTLD. The significance of these findings and the current understanding of the etiology of EBV-N PTLD are discussed.
- Subjects :
- Adult
Male
Epstein-Barr Virus Infections
Pathology
medicine.medical_specialty
Adolescent
Lymphoproliferative disorders
Pilot Projects
Disease
medicine.disease_cause
Virus
Young Adult
Postoperative Complications
Lymphoplasmacytic Infiltrate
Antigen
Risk Factors
hemic and lymphatic diseases
parasitic diseases
medicine
Humans
Child
Aged
Retrospective Studies
Transplantation
Scleroderma, Systemic
business.industry
Organ Transplantation
Middle Aged
medicine.disease
Epstein–Barr virus
Lymphoproliferative Disorders
Post transplant
surgical procedures, operative
Infectious Diseases
Child, Preschool
Immunoglobulin G
Etiology
Female
business
Subjects
Details
- ISSN :
- 13982273
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Transplant Infectious Disease
- Accession number :
- edsair.doi.dedup.....535607b1521b11a70b004bfbe3eb9028