Back to Search
Start Over
Evolution of left ventricular function among subjects with ST-elevation myocardial infarction after percutaneous coronary intervention
- Source :
- BMC Cardiovascular Disorders, BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
-
Abstract
- Background Atrioventricular plane displacement (AVPD) reflects longitudinal left ventricular (LV) systolic function, and wall thickening (WT) regional radial LV function. The temporal evolution of these measures after STEMI with CMR has not been evaluated. We aimed to investigate how AVPD and WT are affected globally and regionally from the sub-acute to the chronic phase after ST-elevation myocardial infarction (STEMI). Methods Healthy volunteers without cardiovascular disease and medication (controls, n = 20) and patients from the CHILL-MI study (NCT01379261) prospectively underwent magnetic resonance imaging (MRI) 2–6 days and 6 months after STEMI (n = 77). CHILL-MI randomized STEMI-patients to cooling therapy initiated before reperfusion or standard of care. AVPD was measured at six points in three long axis cine images and wall thickening in short axis cine images. Infarction was quantified using late gadolinium enhancement (LGE) and used to define infarct and remote segments. Results There were no difference in AVPD either at acute or chronic phase (p = 0.90 and p = 0.40) or WT (p = 0.85 and p = 0.99) between patients randomized to cooling therapy and standard of care. Therefore, the results are presented for the pooled cohort. Global AVPD was decreased in both the sub-acute (12 ± 2 mm, p Conclusion AVPD was a global rather than regional marker of cardiac function in this STEMI study and this may explain the prognostic importance of local measurements of mitral annular plane systolic excursion (MAPSE). The decrease in WT in remote myocardium even in the chronic phase needs to be taken into consideration when combining functional measurements with infarct quantification for diagnosis of post-ischemic stunning and hibernation.
- Subjects :
- Cardiac function curve
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Wall thickening
medicine.medical_treatment
Infarction
Magnetic Resonance Imaging, Cine
030204 cardiovascular system & hematology
Longitudinal function
Ventricular Function, Left
030218 nuclear medicine & medical imaging
STEMI
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Hypothermia, Induced
Internal medicine
medicine.artery
medicine
Humans
Myocardial infarction
Circumflex
cardiovascular diseases
Prospective Studies
Angiology
Aged
business.industry
Left ventricular function
Percutaneous coronary intervention
Middle Aged
medicine.disease
Cardiac surgery
Treatment Outcome
Atrioventricular plane displacement
lcsh:RC666-701
Right coronary artery
Cardiology
cardiovascular system
ST Elevation Myocardial Infarction
Female
Cardiology and Cardiovascular Medicine
business
Radial function
Research Article
Subjects
Details
- ISSN :
- 14712261
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC cardiovascular disorders
- Accession number :
- edsair.doi.dedup.....533fe1de5cdd588e78f689a561bf43aa