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SPARTE Study: Normalization of Arterial Stiffness and Cardiovascular Events in Patients With Hypertension at Medium to Very High Risk
- Source :
- Hypertension (Dallas, Tex. : 1979)
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Supplemental Digital Content is available in the text.<br />The SPARTE study (Strategy for Preventing cardiovascular and renal events based on ARTErial stiffness; URL: https://www.clinicaltrials.gov; Unique identifier: NCT02617238) is a multicenter open-label randomized controlled trial with blinded end point evaluation, undertaken at 25 French research centers in university hospitals. Patients with primary hypertension were randomly assigned (1:1) to a therapeutic strategy targeting the normalization of carotid-femoral pulse wave velocity (PWV) measured every 6 months (PWV group, n=264) versus a classical therapeutic strategy only implementing the European Guidelines for Hypertension Treatment (conventional group, n=272). In the PWV group, the therapeutic strategy used preferably a combination of ACE (angiotensin-converting enzyme) inhibitor or angiotensin receptor blocker and calcium channel blockers, as well as maximal recommended doses of ACE inhibitors and angiotensin receptor blockers. The primary outcome was a combined end point including particularly stroke and coronary events. Secondary outcomes included the time-course changes in brachial office blood pressure (BP), ambulatory BP, PWV, and treatments. After a median follow-up of 48.3 months, there was no significant between-group difference in primary outcome (hazard ratio, 0.74 [95% CI, 0.40–1.38], P=0.35). In the PWV group, combinations of renin-angiotensin-system blockers and calcium channel blockers were prescribed at higher dosage (P=0.028), office and ambulatory systolic blood pressure and diastolic blood pressure decreased more (P
- Subjects :
- Male
medicine.medical_specialty
hypertension
renin-angiotensin system
Pulse Wave Analysis
law.invention
Randomized controlled trial
law
Internal medicine
Internal Medicine
Humans
Medicine
Prospective Studies
Stroke
Pulse wave velocity
surrogate end point
Aged
business.industry
Surrogate endpoint
Hazard ratio
blood pressure
vascular stiffness
clinical trial
Original Articles
Middle Aged
medicine.disease
Blood pressure
Cardiovascular Diseases
Ambulatory
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Arterial stiffness
Cardiology
Arterial Stiffness
Female
business
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....533f9fd1d28df8dde6efe93df4e65a33