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Pharmacologic control of CAR-T cell function using dasatinib
- Source :
- Blood Advances. 3:711-717
- Publication Year :
- 2019
- Publisher :
- American Society of Hematology, 2019.
-
Abstract
- Key Points Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation. Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.
- Subjects :
- 0301 basic medicine
T-Lymphocytes
Antigens, CD19
Dasatinib
Lymphocyte Activation
Cell Line
Mice
03 medical and health sciences
0302 clinical medicine
Antigen
Cell Line, Tumor
hemic and lymphatic diseases
Animals
Humans
Medicine
Receptor
Protein Kinase Inhibitors
Cell Proliferation
Receptors, Chimeric Antigen
business.industry
Hematology
Stimulus Report
030104 developmental biology
Cell culture
030220 oncology & carcinogenesis
Toxicity
Cancer research
Cytokines
Heterografts
Cytokine secretion
Car t cells
business
human activities
Function (biology)
medicine.drug
Subjects
Details
- ISSN :
- 24739537 and 24739529
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Blood Advances
- Accession number :
- edsair.doi.dedup.....5322ac9118675e8b5ca2b2f743fe9cc2
- Full Text :
- https://doi.org/10.1182/bloodadvances.2018028720