Back to Search
Start Over
Postoperative Adjuvant Therapy for Resectable Pancreatic Cancer With Gemcitabine and Adoptive Immunotherapy
- Source :
- Pancreas
- Publication Year :
- 2017
- Publisher :
- Lippincott Williams & Wilkins, 2017.
-
Abstract
- Objectives We previously described adoptive immunotherapy (AIT) with cytotoxic T lymphocytes (CTLs) stimulated by the mucin 1 (MUC1)-expressing human pancreatic cancer cell line YPK-1 (MUC1-CTLs) and demonstrated that MUC1-CTLs might prevent liver metastasis. In the present study, we combined gemcitabine (GEM) and AIT for the treatment of pancreatic cancer. Methods A total of 43 patients who underwent radical pancreatectomy received treatment with MUC1-CTLs and GEM. After surgery, MUC1-CTLs were induced and administered intravenously 3 times, and GEM administered according to the standard regimen for 6 months. The patients whose relative dose intensity of GEM was 50% or more and who received 2 or more MUC1-CTL treatments were used as the adequate treatment group (n = 21). Results In the adequate treatment group, disease-free survival was 15.8 months, and overall survival was 24.7 months. Liver metastasis was found only in 7 patients (33%), and local recurrence occurred in 4 patients (19%). The independent prognostic factor of long-term disease-free survival on multivariate analysis was the average number of CTLs administered (P = 0.0133). Conclusions The combination therapy with AIT and GEM prevented liver metastasis and local recurrence. Moreover, the disease free-survival was improved in patients who received sufficient CTLs.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
medicine.medical_specialty
Antimetabolites, Antineoplastic
Combination therapy
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
pancreatic cancer
MUC1
Kaplan-Meier Estimate
Deoxycytidine
Immunotherapy, Adoptive
Metastasis
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Pancreatic cancer
Internal Medicine
medicine
Adjuvant therapy
Humans
Postoperative Period
Aged
Aged, 80 and over
Hepatology
business.industry
Liver Neoplasms
Immunotherapy
Original Articles
Leukopenia
Middle Aged
medicine.disease
Combined Modality Therapy
Gemcitabine
Pancreatic Neoplasms
Regimen
030104 developmental biology
030220 oncology & carcinogenesis
Pancreatectomy
Multivariate Analysis
Female
Neoplasm Recurrence, Local
business
adoptive immunotherapy
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 15364828 and 08853177
- Volume :
- 46
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....5321c871bca651f279fafb5ce227d7dd