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Distribution and disappearance of the radiolabeled carbon derived from L-arginine and taurine in the mouse
- Source :
- Life Sciences. 60:2373-2381
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- L-arginine and taurine are still in the center of physiological and pharmacological research. Although the fate of nitrogen of both compounds and of the 35S-taurine is well-documented, the fate of the carbon skeleton has not been elucidated yet. We studied the organ distribution of 14C arginine and 14C taurine over time in the mouse using whole body autoradiography with densitometric image analysis. We describe different organ distribution patterns. Kidney, heart, lung, the Harderian gland, the central nervous system, intestine and testis showed a comparable pattern of arginine disappearance in contrast to rapid disappearance in the salivary gland and the accumulation pattern in bone and spleen. Data on 14C taurine of liver, kidneys, lung, testis and Harderian gland resembled the arginine pattern; Accumulation of taurine carbon was found in salivary gland, bone, intestine, heart and brain. Our studies challenge and demand further related studies to obtaining more information on the fate of the carbon skeleton of these amino acids.
- Subjects :
- Male
medicine.medical_specialty
Taurine
Arginine
Central nervous system
Spleen
Biology
General Biochemistry, Genetics and Molecular Biology
Mice
Harderian gland
chemistry.chemical_compound
Internal medicine
medicine
Animals
Tissue Distribution
General Pharmacology, Toxicology and Pharmaceutics
chemistry.chemical_classification
Carbon Isotopes
Kidney
Salivary gland
General Medicine
Amino acid
medicine.anatomical_structure
Endocrinology
Biochemistry
chemistry
Autoradiography
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....5320c12e5c24d76bf6c1192b4071e164