Figures S1-5 & Tables S2-5 from Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer

Figure S1. Chemical structure, Figure S2. Kinase selectivity, Figure S3. PK, Figure S4. Inhibition of proliferation and induction of apoptosis in vivo, Figure S5. TP53 sequencing, Table S2. Crystallographic data collection, Table S3. Genes changed by 1 uM CH7057288 treatment, Table S4. Upstream regulators, Table S5. The Caco-2 permeability assay