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Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties
- Source :
- European spine journal, 22 (2013): S979–S984. doi:10.1007/s00586-013-3028-6, info:cnr-pdr/source/autori:Brodano G.B.; Terzi S.; Trombi L.; Griffoni C.; Valtieri M.; Boriani S.; Magli M.C./titolo:Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties/doi:10.1007%2Fs00586-013-3028-6/rivista:European spine journal (Print)/anno:2013/pagina_da:S979/pagina_a:S984/intervallo_pagine:S979–S984/volume:22
- Publication Year :
- 2013
- Publisher :
- Springer Berlin Heidelberg, 2013.
-
Abstract
- Purpose Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application. Methods We proposed to analyze the in vitro growth kinetics of MSCs derived from different body sites (iliac crest bone marrow, vertebrae bone marrow, colon mucosa, dental pulp). Results Mesenchymal stem cells derived from vertebrae can be maintained in culture for a greater number of steps and they also generate mature cells of all mesenchymal lineages with greater efficiency, when induced into osteogenic, adipogenic and chondrogenic differentiation. Conclusions The ability of vertebrae-derived MSCs in terms of expansion and differentiation is very interesting at the light of a clinical application for bone fusion in spine surgery. © Springer-Verlag Berlin Heidelberg 2013.
- Subjects :
- business.industry
Cellular differentiation
Mesenchymal stem cell
Clinical uses of mesenchymal stem cells
Bone Marrow Cells
Cell Differentiation
Mesenchymal Stem Cells
Spine
Cell biology
Spine fusion
Biological property
Differentiation
Medicine
Humans
Orthopedics and Sports Medicine
Surgery
Vertebraderived bone marrow
Original Article
In vitro growth
business
Cells, Cultured
Stem cell transplantation for articular cartilage repair
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- European spine journal, 22 (2013): S979–S984. doi:10.1007/s00586-013-3028-6, info:cnr-pdr/source/autori:Brodano G.B.; Terzi S.; Trombi L.; Griffoni C.; Valtieri M.; Boriani S.; Magli M.C./titolo:Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties/doi:10.1007%2Fs00586-013-3028-6/rivista:European spine journal (Print)/anno:2013/pagina_da:S979/pagina_a:S984/intervallo_pagine:S979–S984/volume:22
- Accession number :
- edsair.doi.dedup.....530eb1a7b642bca6852f2c3bbed40d10