Back to Search
Start Over
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
- Source :
- Bioorganic & Medicinal Chemistry Letters. 18:4838-4843
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Piperazines
Amidohydrolases
Amidase
Mice
chemistry.chemical_compound
Fatty acid amide hydrolase
Thiadiazoles
Drug Discovery
Animals
Urea
Molecular Biology
Mice, Knockout
chemistry.chemical_classification
Aryl
Organic Chemistry
Anandamide
Piperazine
Enzyme
chemistry
Covalent bond
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....52fa7be7ec1200469cf9e6da14674efa
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.07.081