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ABCA12 regulates insulin secretion from β‐cells
- Source :
- EMBO Rep
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Dysregulation of lipid homeostasis is intimately associated with defects in insulin secretion, a key feature of type 2 diabetes. Here, we explore the role of the putative lipid transporter ABCA12 in regulating insulin secretion from β-cells. Mice with β-cell-specific deletion of Abca12 display impaired glucose-stimulated insulin secretion and eventual islet inflammation and β-cell death. ABCA12's action in the pancreas is independent of changes in the abundance of two other cholesterol transporters, ABCA1 and ABCG1, or of changes in cellular cholesterol or ceramide content. Instead, loss of ABCA12 results in defects in the genesis and fusion of insulin secretory granules and increases in the abundance of lipid rafts at the cell membrane. These changes are associated with dysregulation of the small GTPase CDC42 and with decreased actin polymerisation. Our findings establish a new, pleiotropic role for ABCA12 in regulating pancreatic lipid homeostasis and insulin secretion.
- Subjects :
- Ceramide
medicine.medical_treatment
Inflammation
Biochemistry
Cell membrane
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Insulin-Secreting Cells
Insulin Secretion
Genetics
medicine
Animals
Insulin
Molecular Biology
Lipid raft
030304 developmental biology
0303 health sciences
biology
Chemistry
Articles
Cell biology
medicine.anatomical_structure
Glucose
Diabetes Mellitus, Type 2
ABCA1
biology.protein
lipids (amino acids, peptides, and proteins)
ATP-Binding Cassette Transporters
medicine.symptom
Pancreas
030217 neurology & neurosurgery
Homeostasis
ATP Binding Cassette Transporter 1
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- EMBO Rep
- Accession number :
- edsair.doi.dedup.....52df1a938c36888ea1e995a19b81210b