Back to Search
Start Over
Abnormal c-fos expression in the lateral habenula during dystonic attacks in a hamster model of idiopathic dystonia
- Source :
- Brain research. 728(1)
- Publication Year :
- 1996
-
Abstract
- The genetically dystonic hamster (dtsz), an animal model of idiopathic dystonia, displays sustained twisting movements and postures either spontaneously or in response to mild stress. In the present study the expression of c-fos immunoreactive neurons (Fos-ir), used as an indicator of neuronal activity, was investigated within various brain regions in dtsz hamsters and non-dystonic control hamsters. Under baseline condition, i.e. in the absence of dystonia, the expression of Fos-ir did not reveal any differences between dtsz hamsters and controls. However, in response to mild stress several brain regions, particularly the lateral habenula (LHb), exhibited differences in c-fos induction in dtsz hamsters and controls. Whereas in the LHb the expression of Fos-ir was markedly enhanced in controls, it showed almost no increase in dystonic hamsters, indicating impaired neuronal activity. Since the lateral habenula receives major input from the basal ganglia via the entopeduncular nucleus, the present data might indicate that basal ganglia are involved in the dystonic syndrome in mutant hamsters.
- Subjects :
- Male
medicine.medical_specialty
Transcription, Genetic
Central nervous system
Hamster
Nerve Tissue Proteins
c-Fos
Internal medicine
Cricetinae
Basal ganglia
medicine
Premovement neuronal activity
Animals
Molecular Biology
Dystonia
Neurons
Habenula
biology
General Neuroscience
medicine.disease
Immunohistochemistry
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Mutation
biology.protein
Female
Neurology (clinical)
Basal Metabolism
Immediate early gene
Proto-Oncogene Proteins c-fos
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 728
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Brain research
- Accession number :
- edsair.doi.dedup.....52dc65ccf3b384ee34e631875849de39