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Roles of mitochondria in neutrophils

Roles of mitochondria in neutrophils

Authors :
Ziming Cao
Meng Zhao
Hao Sun
Liang Hu
Yunfeng Chen
Zhichao Fan
Source :
Frontiers in immunology. 13
Publication Year :
2022

Abstract

Neutrophils are the most abundant leukocyte in human blood. They are critical for fighting infections and are involved in inflammatory diseases. Mitochondria are indispensable for eukaryotic cells, as they control the biochemical processes of respiration and energy production. Mitochondria in neutrophils have been underestimated since glycolysis is a major metabolic pathway for fuel production in neutrophils. However, several studies have shown that mitochondria are greatly involved in multiple neutrophil functions as well as neutrophil-related diseases. In this review, we focus on how mitochondrial components, metabolism, and related genes regulate neutrophil functions and relevant diseases.

Details

ISSN :
16643224
Volume :
13
Database :
OpenAIRE
Journal :
Frontiers in immunology
Accession number :
edsair.doi.dedup.....52d752ebf3755895f06c3505e3beb0d4