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Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study
- Source :
- Respiratory Research
- Publisher :
- Springer Nature
-
Abstract
- Background Asthma is a heterogeneous disease and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. The purpose of the ADEPT study was to correlate clinical features and biomarkers with molecular characteristics, by profiling asthma (NCT01274507). This report presents for the first time the study design, and characteristics of the recruited subjects. Methods Patients with a range of asthma severity and healthy non-atopic controls were enrolled. The asthmatic subjects were followed for 12 months. Assessments included history, patient questionnaires, spirometry, airway hyper-responsiveness to methacholine, fractional exhaled nitric oxide (FENO), and biomarkers measured in induced sputum, blood, and bronchoscopy samples. All subjects underwent sputum induction and 30 subjects/cohort had bronchoscopy. Results Mild (n = 52), moderate (n = 55), severe (n = 51) asthma cohorts and 30 healthy controls were enrolled from North America and Western Europe. Airflow obstruction, bronchodilator response and airways hyperresponsiveness increased with asthma severity, and severe asthma subjects had reduced forced vital capacity. Asthma control questionnaire-7 (ACQ7) scores worsened with asthma severity. In the asthmatics, mean values for all clinical and biomarker characteristics were stable over 12 months although individual variability was evident. FENO and blood eosinophils did not differ by asthma severity. Induced sputum eosinophils but not neutrophils were lower in mild compared to the moderate and severe asthma cohorts. Conclusions The ADEPT study successfully enrolled asthmatics across a spectrum of severity and non-atopic controls. Clinical characteristics were related to asthma severity and in general asthma characteristics e.g. lung function, were stable over 12 months. Use of the ADEPT data should prove useful in defining biological phenotypes to facilitate personalized therapeutic approaches. Electronic supplementary material The online version of this article (doi:10.1186/s12931-015-0299-y) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
Vital capacity
Time Factors
Personalized
Anti-asthmatic Agent
Severity of Illness Index
Risk Factors
Bronchodilator
Surveys and Questionnaires
Prevalence
Anti-Asthmatic Agents
Longitudinal Studies
Precision Medicine
Lung
medicine.diagnostic_test
Middle Aged
Bronchodilator Agents
Respiratory Function Tests
Europe
Phenotypes
Phenotype
Treatment Outcome
Research Design
Female
medicine.symptom
Spirometry
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Canada
Adolescent
medicine.drug_class
Bronchoconstriction
macromolecular substances
Severity
Young Adult
Predictive Value of Tests
Internal medicine
Severity of illness
medicine
Humans
Asthma
Aged
business.industry
Research
Profiling
Patient Selection
Sputum
medicine.disease
United States
Surgery
respiratory tract diseases
Case-Control Studies
Exhaled nitric oxide
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 1465993X
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Respiratory Research
- Accession number :
- edsair.doi.dedup.....52d3f895e65407ae1d541510dcebff32
- Full Text :
- https://doi.org/10.1186/s12931-015-0299-y