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Boron encapsulated in a liposome can be used for combinational neutron capture therapy

Authors :
Jiyuan Li
Qi Sun
Chuanjie Lu
Han Xiao
Zhibin Guo
Dongban Duan
Zizhu Zhang
Tong Liu
Zhibo Liu
Source :
Nature communications. 13(1)
Publication Year :
2021

Abstract

Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irradiation and therapeutic outcomes are further improved by encapsulation of chemotherapy drugs, especially with PARP1 inhibitors. In sum, boronsome may be an efficient agent for concurrent chemoradiotherapy with theranostic properties against malignancies.

Details

ISSN :
20411723
Volume :
13
Issue :
1
Database :
OpenAIRE
Journal :
Nature communications
Accession number :
edsair.doi.dedup.....52d360042c94a643762458c864ac2ab6