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Photoinduced apoptosis using a peptide carrying a photosensitizer
- Source :
- Bioorganic & Medicinal Chemistry Letters. 26:3115-3118
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- A novel molecule, TatBim-Alexa, consisting of the HIV1 Tat cell-penetrating peptide, the Bim apoptosis-inducing peptide, and Alexa Fluor 546 was synthesized for photoinducion of apoptosis. The Alexa Fluor 546 was used as a photosensitizer and covalently attached at the C-terminus of TatBim peptide by the thiol-maleimide reaction. Photo-dependent cytosolic internalization of TatBim-Alexa and photo-dependent apoptosis using TatBim-Alexa were demonstrated in several kinds of mammalian cells including human cancer cell lines.
- Subjects :
- 0301 basic medicine
media_common.quotation_subject
Clinical Biochemistry
Pharmaceutical Science
Antineoplastic Agents
Apoptosis
Peptide
CHO Cells
Biochemistry
Structure-Activity Relationship
03 medical and health sciences
Cricetulus
0302 clinical medicine
Cell Line, Tumor
Drug Discovery
Animals
Humans
Photosensitizer
Internalization
Molecular Biology
Cell Proliferation
Fluorescent Dyes
media_common
Alexa Fluor
chemistry.chemical_classification
Photosensitizing Agents
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Cell growth
Quinolinium Compounds
Chinese hamster ovary cell
Organic Chemistry
Photochemical Processes
030104 developmental biology
030220 oncology & carcinogenesis
Cell-penetrating peptide
Molecular Medicine
Drug Screening Assays, Antitumor
Peptides
HeLa Cells
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....52cea51300339d21600cd606bd196b86