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Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up

Authors :
Andre Van Steirteghem
Johan Smitz
Claire Bourgain
Efstratios M. Kolibianakis
Kaan Osmanagaoglu
Carola Albano
Paul Devroey
Department of Embryology and Genetics
Vrije Universiteit Brussel
Centre for Reproductive Medicine - Gynaecology
Source :
Fertility and Sterility. 78:1025-1029
Publication Year :
2002
Publisher :
Elsevier BV, 2002.

Abstract

Objective: To assess the effect of ovarian stimulation with recombinant FSH, GnRH antagonists, and hCG on endometrial maturation on the day of oocyte pick-up. Design: Prospective study. Setting: Tertiary referral center. Patient(s): Fifty-five women undergoing controlled ovarian hyperstimulation for IVF/intracytoplasmic sperm injection (ICSI). Intervention(s): [1] Ovarian stimulation with recombinant FSH, starting on day 2 of the cycle and GnRH antagonist, starting after a median of 6 days of recombinant FSH stimulation (range, 5–12 days); [2] hCG administration for ovulation induction; and [3] aspirational biopsy of endometrium at oocyte pick-up. Main Outcome Measure(s): Endometrial histology at oocyte pick-up by Noyes criteria. Result(s): Advancement of endometrial maturation (2.5 ± 0.1 days) as compared to the expected chronological date was observed in all antagonist cycles at oocyte retrieval. Endometrial advancement at oocyte pick-up increased in line with values of LH at initiation of stimulation and the duration of recombinant FSH treatment before the antagonist was started. Conclusion(s): The higher the values of LH at initiation of stimulation and the longer the duration of recombinant FSH treatment before the antagonist is started, the more advanced the endometrial maturation at oocyte pick-up.

Details

ISSN :
00150282
Volume :
78
Database :
OpenAIRE
Journal :
Fertility and Sterility
Accession number :
edsair.doi.dedup.....52cc3b71bb73b52479754a2f055ba091
Full Text :
https://doi.org/10.1016/s0015-0282(02)03323-x