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Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up
- Source :
- Fertility and Sterility. 78:1025-1029
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Objective: To assess the effect of ovarian stimulation with recombinant FSH, GnRH antagonists, and hCG on endometrial maturation on the day of oocyte pick-up. Design: Prospective study. Setting: Tertiary referral center. Patient(s): Fifty-five women undergoing controlled ovarian hyperstimulation for IVF/intracytoplasmic sperm injection (ICSI). Intervention(s): [1] Ovarian stimulation with recombinant FSH, starting on day 2 of the cycle and GnRH antagonist, starting after a median of 6 days of recombinant FSH stimulation (range, 5–12 days); [2] hCG administration for ovulation induction; and [3] aspirational biopsy of endometrium at oocyte pick-up. Main Outcome Measure(s): Endometrial histology at oocyte pick-up by Noyes criteria. Result(s): Advancement of endometrial maturation (2.5 ± 0.1 days) as compared to the expected chronological date was observed in all antagonist cycles at oocyte retrieval. Endometrial advancement at oocyte pick-up increased in line with values of LH at initiation of stimulation and the duration of recombinant FSH treatment before the antagonist was started. Conclusion(s): The higher the values of LH at initiation of stimulation and the longer the duration of recombinant FSH treatment before the antagonist is started, the more advanced the endometrial maturation at oocyte pick-up.
- Subjects :
- Adult
endocrine system
medicine.medical_specialty
Pregnancy Rate
medicine.drug_class
Biopsy
medicine.medical_treatment
Fertilization in Vitro
Controlled ovarian hyperstimulation
Gonadotropin-releasing hormone
Biology
Chorionic Gonadotropin
Human chorionic gonadotropin
Gonadotropin-Releasing Hormone
Andrology
Endometrium
Follicle-stimulating hormone
Ovulation Induction
Pregnancy
Internal medicine
medicine
Humans
Prospective Studies
Sperm Injections, Intracytoplasmic
medicine.diagnostic_test
Obstetrics and Gynecology
Oocyte
Recombinant Proteins
medicine.anatomical_structure
Endocrinology
Reproductive Medicine
Oocytes
Tissue and Organ Harvesting
Female
Ovulation induction
Follicle Stimulating Hormone
Gonadotropin
hormones, hormone substitutes, and hormone antagonists
Endometrial biopsy
Subjects
Details
- ISSN :
- 00150282
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Fertility and Sterility
- Accession number :
- edsair.doi.dedup.....52cc3b71bb73b52479754a2f055ba091
- Full Text :
- https://doi.org/10.1016/s0015-0282(02)03323-x