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Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex
- Source :
- Neuron; Vol 71, Neuron
- Publication Year :
- 2011
-
Abstract
- SummaryA fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neurons accompanies functional changes is less clear. Here, we use two-photon imaging to monitor the fine structure of inhibitory neurons in mouse visual cortex after deprivation induced by retinal lesions. We find that a subset of inhibitory neurons carry dendritic spines, which form glutamatergic synapses. Removal of visual input correlates with a rapid and lasting reduction in the number of inhibitory cell spines. Similar to the effects seen for dendritic spines, the number of inhibitory neuron boutons dropped sharply after retinal lesions. Together, these data suggest that structural changes in inhibitory neurons may precede structural changes in excitatory circuitry, which ultimately result in functional adaptation following sensory deprivation.
- Subjects :
- Diagnostic Imaging
Dendritic spine
Time Factors
Sensory Receptor Cells
Neuroscience(all)
Dendritic Spines
Green Fluorescent Proteins
Presynaptic Terminals
Glutamic Acid
Sensory system
Mice, Transgenic
Visual system
Biology
In Vitro Techniques
Inhibitory postsynaptic potential
Retina
03 medical and health sciences
Glutamatergic
Mice
0302 clinical medicine
Animals
Sensory deprivation
Neuropeptide Y
Visual Pathways
gamma-Aminobutyric Acid
030304 developmental biology
Visual Cortex
0303 health sciences
Brain Mapping
Glutamate Decarboxylase
General Neuroscience
Neural Inhibition
nervous system
Inhibitory Postsynaptic Potentials
Vesicular Glutamate Transport Protein 1
Excitatory postsynaptic potential
Sensory Deprivation
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10974199
- Volume :
- 71
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....52b8c7eaab4f744c63c50d17ba4ed39c