Back to Search
Start Over
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
- Source :
- Repositório Digital do Instituto Evandro Chagas (Patuá), Instituto Evandro Chagas (IEC), instacron:IEC, Nature Communications, Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection. Here we report that the same mutation confers NS1 to inhibit interferon-β induction. This mutation enables NS1 binding to TBK1 and reduces TBK1 phosphorylation. Engineering the mutation into a pre-epidemic ZIKV strain debilitates the virus for interferon-β induction; reversing the mutation in an epidemic ZIKV strain invigorates the virus for interferon-β induction; these mutational effects are lost in IRF3-knockout cells. Additionally, ZIKV NS2A, NS2B, NS4A, NS4B, and NS5 can also suppress interferon-β production through targeting distinct components of the RIG-I pathway; however, for these proteins, no antagonistic difference is observed among various ZIKV strains. Our results support the mechanism that ZIKV has accumulated mutation(s) that increases the ability to evade immune response and potentiates infection and epidemics.<br />The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in mice.
- Subjects :
- 0301 basic medicine
Mutag?nese / imunologia
Lineage (genetic)
Infec??o pelo Zika virus / diagn?stico
Science
viruses
030106 microbiology
General Physics and Astronomy
Biology
Protein Serine-Threonine Kinases
Viral Nonstructural Proteins
General Biochemistry, Genetics and Molecular Biology
Virus
Article
Zika virus
Evolution, Molecular
03 medical and health sciences
Immune system
TANK-binding kinase 1
Interferon
medicine
Humans
lcsh:Science
Gene
Phylogeny
Immune Evasion
Multidisciplinary
Zika Virus Infection
virus diseases
General Chemistry
Zika Virus
biology.organism_classification
Virology
humanities
3. Good health
Zika virus / patogenicidade
030104 developmental biology
Mutation (genetic algorithm)
Mutation
lcsh:Q
Interferons
Intera??es Hospedeiro-Parasita / imunologia
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Digital do Instituto Evandro Chagas (Patuá), Instituto Evandro Chagas (IEC), instacron:IEC, Nature Communications, Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
- Accession number :
- edsair.doi.dedup.....52b64f257e751ccd0b1ae640c2e0b489