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Synthesis of Chiral Thiourea-Thioxanthone Hybrids
- Source :
- Synthesis
-
Abstract
- Four different 1-aminocyclohexanes bearing a tethered thioxanthone group in the 2-position were prepared. The synthesis commenced with the respective N-protected β-amino acids, the carboxyl group of which was employed for the introduction of the thioxanthone moiety. After construction of the thioxanthone and protecting group removal, the conversion of the amino group into the respective thiourea was accomplished by treatment with N-3,5-bis(trifluoromethyl)phenyl isothiocyanate and yielded the title compounds in which the thioxanthone resides in different spatial positions relative to the thiourea motif. Overall yields varied between 20–35%.
- Subjects :
- esterification
oxazoles
thioxanthone
indium
010402 general chemistry
01 natural sciences
Medicinal chemistry
Catalysis
chemistry.chemical_compound
Moiety
Organic chemistry
Protecting group
thiourea
chemistry.chemical_classification
amino acids
Trifluoromethyl
photochemistry
010405 organic chemistry
Phenyl isothiocyanate
paper
Organic Chemistry
Thioxanthone
chiral pool
0104 chemical sciences
Amino acid
chemistry
Thiourea
Subjects
Details
- Language :
- English
- ISSN :
- 1437210X and 00397881
- Volume :
- 49
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi.dedup.....52a4136329afa346bd4c35d63cb1bbca
- Full Text :
- https://doi.org/10.1055/s-0036-1590931