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Decline in age-dependent, MK801-induced injury coincides with developmental switch in parvalbumin expression: cingulate and retrosplenial cortex
- Source :
- Developmental psychobiology. 49(6)
- Publication Year :
- 2007
-
Abstract
- Age-dependent, MK801-induced, activated caspase-3 expression in the postnatal brain is generally not observed in neurons expressing calcium-binding proteins (CaBPs), suggesting that apoptosis and calcium buffering are inversely related. In regions such as the cingulate and retrosplenial cortex, injury peaks at postnatal Day 7 (P7) and rapidly diminishes thereafter, whereas expression of calbindin (CB) and calretinin (CR) was relatively low from P0 to P7 and steadily increased from P7 to P14. At ages thereafter, CB and CR expression either remained stable then declined or rapidly declined. Parvalbumin (PV) was generally low-absent prior to P7 but expression dramatically increased from P10 onwards, peaking at P21. These studies suggest calcium entry (through N-methyl-D-aspartate receptor (NMDARs)) and buffering (by CaBPs) are integral to normal CNS maturation. Because schizophrenia is associated with glutamate hypo-function, developmental injury, and aberrant CaBP expression, our data indicate that this postnatal brain injury model may offer important insights into the nature of this disorder.
- Subjects :
- medicine.medical_specialty
Calcium buffering
Glutamic Acid
Cell Count
Calbindin
Gyrus Cinguli
Receptors, N-Methyl-D-Aspartate
Behavioral Neuroscience
S100 Calcium Binding Protein G
Developmental Neuroscience
Retrosplenial cortex
Internal medicine
Developmental and Educational Psychology
medicine
Animals
Calcium metabolism
Cerebral Cortex
biology
Caspase 3
Glutamate receptor
Age Factors
Immunohistochemistry
Rats
Endocrinology
Parvalbumins
nervous system
Brain Injuries
Calbindin 2
biology.protein
NMDA receptor
Calcium
Calretinin
Dizocilpine Maleate
Neuroscience
Excitatory Amino Acid Antagonists
Parvalbumin
Developmental Biology
Subjects
Details
- ISSN :
- 00121630
- Volume :
- 49
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Developmental psychobiology
- Accession number :
- edsair.doi.dedup.....529b3490e5b9c5e1ae978fe559ea0e87