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Increased fetal cell trafficking in murine lung following complete pregnancy loss from exposure to lipopolysaccharide
- Source :
- Fertility and sterility. 93(5)
- Publication Year :
- 2009
-
Abstract
- To determine whether chemically induced miscarriage affects fetomaternal trafficking in a mouse model, we measured the amount of fetal DNA present in various maternal organs by polymerase chain reaction amplification following exposure to lipopolysaccharide (LPS). As the frequency of fetal cells and the number of animals with detectable microchimerism following LPS injection were significantly increased, particularly in lung tissue compared to controls, with no signs of an inflammatory response, we conclude that LPS-induced miscarriage results in increased murine fetomaternal cell trafficking, supporting a relationship between fetal loss and the establishment of fetal cell microchimerism.
- Subjects :
- Lipopolysaccharides
Male
medicine.medical_specialty
Lipopolysaccharide
Ratón
Cell
Green Fluorescent Proteins
Gestational Age
Mice, Transgenic
Chimerism
Polymerase Chain Reaction
Article
Miscarriage
chemistry.chemical_compound
Mice
Fetus
Cell Movement
Pregnancy
Internal medicine
medicine
Animals
Lung
Maternal-Fetal Exchange
business.industry
Obstetrics and Gynecology
Microchimerism
medicine.disease
Abortion, Spontaneous
Mice, Inbred C57BL
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Reproductive Medicine
chemistry
Female
business
Subjects
Details
- ISSN :
- 15565653
- Volume :
- 93
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Fertility and sterility
- Accession number :
- edsair.doi.dedup.....5296545a7706ac7cb4d912e73ffbd997