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Is photodynamic therapy a relevant therapeutic option in refractory benign familial pemphigus (Hailey–Hailey disease)? A series of eight patients
- Source :
- Journal of Dermatological Treatment, Journal of Dermatological Treatment, Informa Healthcare, 2017, 28 (7), pp.678-682. ⟨10.1080/09546634.2017.1308461⟩
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Treatment of benign familial pemphigus or Hailey-Hailey disease (HHD), a rare inherited condition associated with a significant impairment of quality of life, is often challenging and disappointing with frequent relapses and infectious complications. Topical photodynamic therapy (PDT) may offer new perspectives in this difficult setting.Eight patients with long-lasting HHD lesions refractory to multiple treatments were treated on at least one involved site with PDT using methyl-amino levulinate with a standardized protocol of three sessions of irradiation separated by 3-week intervals.A complete or partial clearing was achieved in all treated areas, and the result was satisfactorily maintained in all cases after a follow-up period ranging from 3 to 36 months. Results were of higher quality in non-inguinal areas. Tolerance was overall acceptable with local pain during and shortly after irradiation being the main limiting factor.Our series, although limited in size, emphasizes the interest of PDT in this difficult condition even though results may be incomplete. Treatment-related pain can be adequately managed by prior analgesics, cooling with sprayed water and local tumescent anesthesia. Overall, PDT appears as a relevant option in refractory HHD management with a favorable benefit/risk ratio.
- Subjects :
- Adult
Male
medicine.medical_specialty
Light
Pemphigus, Benign Familial
medicine.medical_treatment
education
Pain
Photodynamic therapy
Dermatology
Disease
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Refractory
Quality of life
Methyl aminolevulinate
medicine
Multiple treatments
Humans
Benign familial pemphigus
Aged
Photosensitizing Agents
business.industry
Drug Tolerance
Middle Aged
medicine.disease
Levulinic Acids
Hailey–Hailey disease
3. Good health
Treatment Outcome
Photochemotherapy
methyl-aminolevulinate
photodynamic therapy
030220 oncology & carcinogenesis
Quality of Life
Female
business
[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 14711753 and 09546634
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Dermatological Treatment
- Accession number :
- edsair.doi.dedup.....52821f085864f98a7686217ba3b95293