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Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies
- Source :
- Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-9 (2017), Peeters, S A, Engelen, L, Buijs, J, Chaturvedi, N, Fuller, J H, Jorsal, A, Parving, H-H, Tarnow, L, Theilade, S, Rossing, P, Schalkwijk, C G & Stehouwer, C D A 2017, ' Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes : pooled analysis of three cohort studies ', Cardiovascular Diabetology, vol. 16, 139 . https://doi.org/10.1186/s12933-017-0620-9, Cardiovascular Diabetology, 16:139. BioMed Central Ltd, Cardiovascular Diabetology
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Background Altered regulation of extracellular matrix (ECM) composition by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) may contribute to arterial stiffening. We investigated associations between circulating MMP-1, -2, -3, -9, -10 and TIMP-1, and carotid-femoral pulse wave velocity (cfPWV) and pulse pressure (PP), as markers of arterial stiffness in type 1 diabetic patients. Methods Individuals with type 1 diabetes from three different cohorts were included in this study: EURODIAB Prospective Complications study (n = 509), LEACE (n = 370) and PROFIL (n = 638). Linear regression analyses were used to investigate cross-sectional associations between circulating levels of MMP-1, -2, -3, -9, -10, and TIMP-1 and cfPWV (n = 614) as well as office PP (n = 1517). Data on 24-h brachial and 24-h central PP were available in 638 individuals from PROFIL. Analyses were adjusted for age, sex, duration of diabetes, HbA1c, mean arterial pressure (MAP), and eGFR, and additionally for other cardiovascular risk factors and presence of vascular complications. Results After adjustment for potential confounders and presence of vascular complications, circulating MMP-3 was associated with cfPWV [β per 1 SD higher lnMMP3 0.29 m/s (0.02; 0.55)]. In addition, brachial and central 24-h PP measurements in PROFIL were significantly associated with MMP-2 [(1.40 (0.47:2.33) and 1.43 (0.63:2.23)]. Pooled data analysis showed significant associations of circulating levels of MMP-1 and MMP-2 with office PP [β per 1 SD higher lnMMP-1 and lnMMP-2 = − 0.83 mmHg (95% CI − 1.50; − 0.16) and = 1.33 mmHg (0.55; 2.10), respectively]. Conclusions MMPs-1, -2, and -3 are independently associated with markers of arterial stiffening in patients with type 1 diabetes and may become therapeutic targets. Electronic supplementary material The online version of this article (doi:10.1186/s12933-017-0620-9) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
CHRONIC KIDNEY-DISEASE
Carotid-femoral pulse wave velocity
lcsh:Diseases of the circulatory (Cardiovascular) system
Endocrinology, Diabetes and Metabolism
BLOOD-PRESSURE
030204 cardiovascular system & hematology
Essential hypertension
Cohort Studies
0302 clinical medicine
Prospective Studies
ESSENTIAL-HYPERTENSION
Pulse wave velocity
Original Investigation
METABOLIC SYNDROME
PULSE PRESSURE
Middle Aged
Arterial stiffness
Europe
Type 1 diabetes
CARDIOVASCULAR-DISEASE
Cardiology
Matrix Metalloproteinase 2
Female
Matrix Metalloproteinase 3
Matrix Metalloproteinase 1
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Mean arterial pressure
EURODIAB PROSPECTIVE COMPLICATIONS
ENDOTHELIAL FUNCTION
030209 endocrinology & metabolism
Tissue inhibitor of metalloproteinase
Pulse Wave Analysis
03 medical and health sciences
Vascular Stiffness
Diabetes mellitus
Internal medicine
EXTRACELLULAR-MATRIX
medicine
Humans
Aged
Tissue Inhibitor of Metalloproteinase-1
business.industry
medicine.disease
Matrix metalloproteinase
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Endocrinology
Blood pressure
Pulse pressure
lcsh:RC666-701
RISK-FACTORS
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....527d3c6bcdadb35dcc128af2586b3fb4