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Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
- Source :
- Neuropharmacology. 38:1917-1920
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
animal diseases
Long-Term Potentiation
Hippocampus
Hippocampal formation
Mice
Cellular and Molecular Neuroscience
Intellectual Disability
mental disorders
Genetic model
medicine
Animals
Long-term depression
Pharmacology
business.industry
musculoskeletal, neural, and ocular physiology
Excitatory Postsynaptic Potentials
Long-term potentiation
medicine.disease
Disease Models, Animal
nervous system
Synaptic plasticity
Excitatory postsynaptic potential
Down Syndrome
Trisomy
business
Neuroscience
Subjects
Details
- ISSN :
- 00283908
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Neuropharmacology
- Accession number :
- edsair.doi.dedup.....527b543f4ea72baad3a6dd345b62c2b1
- Full Text :
- https://doi.org/10.1016/s0028-3908(99)00083-0