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Oxygen metabolism and oxygenation of the newborn
- Publication Year :
- 2020
- Publisher :
- W. B. Saunders Company, 2020.
-
Abstract
- The premature infant is to some extent protected from hypoxia, however defense against hyperoxia is poorly developed. The optimal assessment of oxygenation is to measure oxygen delivery and extraction. At the bedside PaO2 and SpO2 are approximations of oxygenation at the tissue level. After birth asphyxia it is crucial to know whether or not to give oxygen supplementation, when, how much, and for how long. Oxygen saturation targets in the delivery room have been studied, but the optimal targets might still be unknown because factors like gender and delayed cord clamping influence saturation levels. However,SpO2 > 80% at 5 minutes of age is associated with favorable long term outcome in preterm babies. Immature infants most often need oxygen supplementation beyond the delivery room. Predefined saturation levels, and narrow alarm limits might together with the total oxygen exposure may impact on development of oxygen related diseases like ROP and BPD. Hyperoxia is a strong trigger for genetic and epigenetic changes, contributing to the development of these conditions and perhaps lifelong changes.
- Subjects :
- Physiology
chemistry.chemical_element
Infant, Premature, Diseases
Hyperoxia
medicine.disease_cause
Oxygen
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
medicine
Humans
Oximetry
Hypoxia
Asphyxia
business.industry
Oxygen metabolism
Delivery room
Infant, Newborn
Oxygen Inhalation Therapy
Tissue level
Infant
Oxygenation
chemistry
Pediatrics, Perinatology and Child Health
medicine.symptom
business
Oxidative stress
Infant, Premature
Subjects
Details
- ISSN :
- 1744165X
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....527a4707e33e770e7afdc1cffd7a2ece