Back to Search
Start Over
D-Dimer as a potential biomarker for disease severity in COVID-19
- Source :
- The American Journal of Emergency Medicine
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Introduction This study seeks to determine the utility of D-dimer levels as a biomarker in determining disease severity and prognosis in COVID-19. Methods Clinical, imaging and laboratory data of 120 patients whose COVID-19 diagnosis based on RT-PCR were evaluated retrospectively. Clinically, the severity of COVID-19 was classified as noncomplicated or mild or severe pneumonia. Radiologically, the area of affected lungs compatible with viral pneumonia in each patient's computed tomography was classified as either 0–30% or ≥ 31% of the total lung area. The D-dimer values and laboratory data of patients with COVID-19 were compared with inpatient status, duration of hospitalization, and lung involvement during treatment and follow-up. To assess the predictive value of D-dimer, receiver operating characteristic (ROC) analysis was conducted. Results D-dimer elevation (> 243 ng/ml) was detected in 63.3% (76/120) of the patients. The mean D-dimer value was calculated as 3144.50 ± 1709.4 ng/ml (1643–8548) for inpatients with severe pneumonia in the intensive care unit. D-Dimer values showed positive correlations with age, duration of stay, lung involvement, fibrinogen, neutrophil count, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR). When the threshold D-dimer value was 370 ng/ml in the ROC analysis, this value was calculated to have 77% specificity and 74% sensitivity for lung involvement in patients with COVID-19. Conclusion D-Dimer levels in patients with COVID-19 correlate with outcome, but further studies are needed to see how useful they are in determining prognosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Gastroenterology
Severity of Illness Index
Article
Severity
law.invention
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
Young Adult
0302 clinical medicine
law
Internal medicine
Severity of illness
medicine
Humans
Aged
Retrospective Studies
Aged, 80 and over
Receiver operating characteristic
business.industry
SARS-CoV-2
Pulmonary embolism
COVID-19
030208 emergency & critical care medicine
General Medicine
Middle Aged
medicine.disease
Intensive care unit
Pneumonia
Viral pneumonia
D-dimer
Absolute neutrophil count
Emergency Medicine
Biomarker (medicine)
Female
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 07356757
- Database :
- OpenAIRE
- Journal :
- The American Journal of Emergency Medicine
- Accession number :
- edsair.doi.dedup.....5279e8d2629c7a2f5ec89a7014865ba7
- Full Text :
- https://doi.org/10.1016/j.ajem.2020.12.023