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The dual origin of Toxoplasma gondii N-glycans
- Source :
- Biochemistry, Biochemistry, American Chemical Society, 2008, 47 (47), pp.12270-12276. ⟨10.1021/bi801090a⟩, Biochemistry, 2008, 47 (47), pp.12270-12276. ⟨10.1021/bi801090a⟩
- Publication Year :
- 2008
- Publisher :
- HAL CCSD, 2008.
-
Abstract
- International audience; N-Linked glycosylation is the most frequent modification of secreted proteins in eukaryotic cells that plays a crucial role in protein folding and trafficking. Mature N-glycans are sequentially processed in the endoplasmic reticulum and Golgi apparatus through a pathway highly conserved in most eukaryotic organisms. Here, we demonstrate that the obligate intracellular protozoan parasite Toxoplasma gondii independently transfers endogenous truncated as well as host-derived N-glycans onto its own proteins. Therefore, we propose that the apicomplexan parasite scavenges N-glycosylation intermediates from the host cells to compensate for the rapid evolution of its biosynthetic pathway, which is primarily devoted to modification of proteins with glycosylphosphatidylinositols rather than N-glycans.
- Subjects :
- Glycan
Glycosylation
Protozoan Proteins
Oligosaccharides
Saccharomyces cerevisiae
Biochemistry
Cell Line
03 medical and health sciences
chemistry.chemical_compound
symbols.namesake
Polysaccharides
parasitic diseases
Animals
Humans
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
030304 developmental biology
0303 health sciences
biology
Obligate
Endoplasmic reticulum
030302 biochemistry & molecular biology
Glycosyltransferases
Toxoplasma gondii
Golgi apparatus
biology.organism_classification
Cell biology
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
carbohydrates (lipids)
Secretory protein
chemistry
biology.protein
symbols
Protein folding
Mannose
Toxoplasma
Subjects
Details
- Language :
- English
- ISSN :
- 00062960 and 15204995
- Database :
- OpenAIRE
- Journal :
- Biochemistry, Biochemistry, American Chemical Society, 2008, 47 (47), pp.12270-12276. ⟨10.1021/bi801090a⟩, Biochemistry, 2008, 47 (47), pp.12270-12276. ⟨10.1021/bi801090a⟩
- Accession number :
- edsair.doi.dedup.....5257d6dfd773c0f736252ffb85bcaff4