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Conventional vs high-sensitive troponins in acute exacerbations of chronic obstructive pulmonary disease
- Source :
- Heart & Lung. 50:430-436
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Cardiac troponins (cTn), either conventional or high-sensitive (hscTn) assays, are often performed during acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Objectives To compare factors affecting abnormal conventional cTn and hscTn. Methods We retrospectively studied data from AECOPD patients with conventional or hscTn performed at presentation. Binary logistic regression was used to identify predictors for abnormal conventional cTn (>0.5 ug/L) and hscTn (>40 ng/L). Results There were 466 patients in the conventional cTn and 313 patients in the hscTn groups. Ischaemic electrocardiographic change was the only significant predictor for abnormal conventional cTn (OR 6.662 [CI 1.233–35.990], p = 0.028) while B-type natriuretic peptide levels (Adj OR 1.004 [CI 1.000–1.006], p = 0.010) and SpO2/FiO2 ratio (Adj OR 0.115 [CI 0.017–0.069], p = 0.026) were significant predictors of abnormal hscTn. Conclusions Predictors of abnormal cTn differ between assays and should be taken into consideration when interpreting cTn during AECOPD.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Cardiac troponin
medicine.drug_class
Pulmonary disease
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
Logistic regression
Electrocardiographic Change
High sensitive
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Natriuretic peptide
Humans
Myocardial infarction
health care economics and organizations
Retrospective Studies
biology
business.industry
medicine.disease
Troponin
030228 respiratory system
Cardiology
biology.protein
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 01479563
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Heart & Lung
- Accession number :
- edsair.doi.dedup.....5255279b0b43d3d370d6422622d3b5f7