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Sustainable extraction techniques for obtaining antioxidant and anti-inflammatory compounds from the Lamiaceae and Asteraceae species

Authors :
Tiziana Fornari
Guillermo Reglero
María de Las Nieves Siles-Sánchez
Marisol Villalva
Mónica Rodríguez García-Risco
Laura Jaime
Lilia Salas-Pérez
Susana Santoyo
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Comunidad de Madrid
Source :
Digital.CSIC. Repositorio Institucional del CSIC, instname, Foods, Volume 10, Issue 9, Foods, Vol 10, Iss 2067, p 2067 (2021)
Publication Year :
2021
Publisher :
Multidisciplinary Digital Publishing Institute, 2021.

Abstract

This article belongs to the Special Issue Phenolic Compounds in Herbs: Characterization, Antioxidant Properties and Health Benefits.<br />Melissa officinalis L. and Origanum majorana L., within Lamiaceae family, and Calendula officinalis L. and Achillea millefolium L., within the Asteraceae, have been considered a good source of bioactive ingredients with health benefits. In this study, the supercritical fluid extraction (SFE) using pure CO2, and the ultrasound assisted extraction (UAE) were proposed as green techniques to obtain plant-based extracts with potential antioxidant and anti-inflammatory activities. Higher values of total phenolic content and antioxidant activity were achieved in UAE ethanol:water (50:50, v/v) extracts. Meanwhile, UAE pure ethanol extracts showed greater anti-inflammatory activity. RP-HPLC-PAD-ESI-QTOF-MS/MS analysis showed a vast number of phenolic compounds in the extracts, including unreported ones. O. majorana ethanol:water extract presented the highest content of phenolics and antioxidant activity; among its composition, both rosmarinic acid and luteolin glucoside derivatives were abundant. The pure ethanol extract of A. millefolium resulted in an important content of caffeoylquinic acid derivatives, luteolin-7-O-glucoside and flavonoid aglycones, which could be related to the remarkable inhibition of TNF-α, IL-1β and IL-6 cytokines. Besides, borneol and camphor, found in the volatile fraction of A. millefolium, could contributed to this latter activity. Thus, this study points out that O. majorana and A. millefolium are considered a promising source of bioactive ingredients with potential use in health promotion.<br />Authors thanks to the Spanish Government (Project: PID2019-110183RB-C22/AEI/10.13039/501100011033) and Comunidad Autónoma de Madrid (ALIBIRD2020-CM (S2018/BAA-4343)) for financial support.

Details

Database :
OpenAIRE
Journal :
Digital.CSIC. Repositorio Institucional del CSIC, instname, Foods, Volume 10, Issue 9, Foods, Vol 10, Iss 2067, p 2067 (2021)
Accession number :
edsair.doi.dedup.....5248417e52b17c1afd4455062ac4b03a