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Bimatoprost 0.03% Versus Brimonidine 0.2% in the Prevention of Intraocular Pressure Spike Following Neodymium:Yttrium–Aluminum–Garnet Laser Posterior Capsulotomy
- Source :
- Journal of Ocular Pharmacology and Therapeutics. 26:513-517
- Publication Year :
- 2010
- Publisher :
- Mary Ann Liebert Inc, 2010.
-
Abstract
- The aim of this study was to compare the efficacy of bimatoprost 0.03% with brimonidine 0.2% in preventing intraocular pressure (IOP) elevations after neodymium:yttrium–aluminum–garnet (Nd:YAG) laser posterior capsulotomy.In this prospective, randomized, double-masked study, 195 eyes of 195 consecutive patients who had YAG laser capsulotomy for posterior capsule opacification were recruited. Eyes received either 1 drop of bimatoprost 0.03% (98 patients) or brimonidine 0.2% (97 patients) at 1h before laser surgery. A masked observer measured IOP by Goldmann applanation tonometry before treatment and after treatment at 1h, 3h, 24h, and 7 days. Inflammation was evaluated after surgery. Formation of cystoid macular edema was assessed by measuring the macular thickness before and after laser surgery.The average peak of postoperative IOP elevation was 2.2±3.9mm Hg in the bimatoprost 0.03% and 3.6±3.1mm Hg in the brimonidine 0.2% group. The difference was statistically significant (P0.001). Postoperative IOP elevations of 10mm Hg or more occurred in 1 eye (1.56%) in the bimatoprost 0.03% group and 5 eyes (7.35%) in the brimonidine 0.2%. This difference was statistically significant (P0.001). Macular edema and anterior chamber reaction were not observed related to bimatoprost. No clinically significant side effects were noted in either group.Our results indicate that prophylactic use of bimatoprost 0.03% is more effective than brimonidine 0.2% in preventing IOP elevation immediately after YAG laser capsulotomy. Bimatoprost 0.03% as a prostamide analog may provide new option for preventing IOP elevation after YAG laser capsulotomy.
- Subjects :
- Male
Laser surgery
medicine.medical_specialty
Intraocular pressure
genetic structures
medicine.medical_treatment
Lasers, Solid-State
Cataract
Tonometry, Ocular
Brimonidine Tartrate
Quinoxalines
medicine
Glaucoma surgery
Humans
Pharmacology (medical)
Posterior Capsulotomy
Antihypertensive Agents
Intraocular Pressure
Aged
Aged, 80 and over
Neodymium
Pharmacology
Bimatoprost
business.industry
Brimonidine
Cloprostenol
Glaucoma
Capsule Opacification
Middle Aged
Amides
eye diseases
Surgery
Ophthalmology
Posterior Capsule of the Lens
Capsulotomy
Female
Ocular Hypertension
Laser Therapy
sense organs
Ophthalmic Solutions
business
medicine.drug
Subjects
Details
- ISSN :
- 15577732 and 10807683
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Ocular Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....5246f00f4388150a6b360c72e453899c