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Regulation of lysosomal positioning via TMEM55B phosphorylation
- Source :
- The Journal of Biochemistry. 169:507-509
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Lysosomes are dynamic organelles that are transported along microtubules bidirectionally via kinesin and dynein motor proteins. Lysosomal positioning, which is determined by the balance of the bidirectional lysosomal movement, changes under various conditions and affects lysosomal functions such as autophagy and antigen presentation. A recent study by Takemasu et al. (Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. J. Biochem. 2019; 166:175–185) has shown that phosphorylation of the transmembrane protein TMEM55B is involved in the retrograde lysosomal trafficking towards the perinuclear region. They found that TMEM55B is phosphorylated upon stimulation with various ligands and that Erk/MAPK mediates the TMEM55B phosphorylation. They have also revealed that a phosphorylation mimic mutant of TMEM55B enhances perinuclear lysosomal clustering compared to the wild-type TMEM55B. These findings suggest that TMEM55B phosphorylation by Erk/MAPK is responsible for regulating lysosomal positioning in response to external stimuli.
- Subjects :
- MAPK/ERK pathway
MAP Kinase Signaling System
Dynein
Vesicular Transport Proteins
macromolecular substances
Biochemistry
03 medical and health sciences
0302 clinical medicine
Microtubule
Dynein ATPase
Animals
Humans
Phosphorylation
Molecular Biology
030304 developmental biology
0303 health sciences
Chemistry
Autophagy
General Medicine
Transmembrane protein
Cell biology
Kinesin
Phosphoinositide Phosphatases
Lysosomes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17562651 and 0021924X
- Volume :
- 169
- Database :
- OpenAIRE
- Journal :
- The Journal of Biochemistry
- Accession number :
- edsair.doi.dedup.....523d0fa7b25d19a2d5df619ee4651753