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HEN-1, a Secretory Protein with an LDL Receptor Motif, Regulates Sensory Integration and Learning in Caenorhabditis elegans
- Source :
- Cell. (5):639-649
- Publisher :
- Cell Press.
-
Abstract
- Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.
- Subjects :
- Nervous system
Bodily Secretions
Mutant
Amino Acid Motifs
Sensation
Sensory system
Nerve Tissue Proteins
Nervous System
General Biochemistry, Genetics and Molecular Biology
Evolution, Molecular
Neural Pathways
medicine
Animals
Learning
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Phylogeny
Homeodomain Proteins
Neurons
biology
Biochemistry, Genetics and Molecular Biology(all)
Neuropeptides
Anatomy
biology.organism_classification
Cell biology
Secretory protein
medicine.anatomical_structure
Phenotype
Gene Expression Regulation
Receptors, LDL
LDL receptor
Motif (music)
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....522e7d38287843b35327dad83a3df798
- Full Text :
- https://doi.org/10.1016/S0092-8674(02)00748-1