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Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss

Authors :
D. Graterol
C. Garcia-Vaquero
M. I. Rochera-Villach
Cristina Mir
Alex Lyakhovich
Matilde E. Lleonart
I. Braña
Juan Lorente
A. N. Pardo
Source :
International Journal of Otolaryngology, International Journal of Otolaryngology, Vol 2017 (2017)
Publication Year :
2017
Publisher :
Hindawi, 2017.

Abstract

Background.Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity.Objective.We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss.Study Design and Methods.This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined.Results.40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor.Conclusions.Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.

Details

Language :
English
ISSN :
16879201
Database :
OpenAIRE
Journal :
International Journal of Otolaryngology
Accession number :
edsair.doi.dedup.....52268b07d4adae9a893937e847e84645
Full Text :
https://doi.org/10.1155/2017/5185268