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Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss
- Source :
- International Journal of Otolaryngology, International Journal of Otolaryngology, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi, 2017.
-
Abstract
- Background.Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity.Objective.We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss.Study Design and Methods.This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined.Results.40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor.Conclusions.Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Article Subject
Hearing loss
lcsh:Surgery
Audiology
Haplogroup
03 medical and health sciences
Ototoxicity
Internal medicine
otorhinolaryngologic diseases
Medicine
Cisplatin
Cardiotoxicity
medicine.diagnostic_test
business.industry
lcsh:RD1-811
General Medicine
lcsh:Otorhinolaryngology
medicine.disease
lcsh:RF1-547
030104 developmental biology
Cohort
medicine.symptom
Audiometry
business
Research Article
Human mitochondrial DNA haplogroup
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16879201
- Database :
- OpenAIRE
- Journal :
- International Journal of Otolaryngology
- Accession number :
- edsair.doi.dedup.....52268b07d4adae9a893937e847e84645
- Full Text :
- https://doi.org/10.1155/2017/5185268