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Circulating activated protein C is reduced in young survivors of myocardial infarction and inversely correlates with the severity of coronary lesions
- Source :
- Journal of thrombosis and haemostasis : JTH, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Summary. Background: Cardiovascular risk factors for myocardial infarction (MI) are less frequent in younger than in older MI survivors. Therefore, the thrombotic component of MI may play a more important role at a young age. As activated protein C (APC) provides systemic anticoagulant and anti-inflammatory protection, a low plasma APC level may be an arterial thrombotic risk factor. Aim: To determine whether there is an association between reduced APC levels and early MI and severe coronary lesions. Methods: APC was measured in 231 young MI survivors and 231 controls. Results: Low APC levels were significantly associated with MI. Compared with the fourth quartile, the odds ratio (OR) for APC values in the first quartile was 3.7 [95% confidence interval (CI) = 2.1–6.4], and 3.2 (1.5–7.0) after adjustment for cardiovascular risk factors. Moreover, each decrease of 0.43 ng mL−1 (1 SD) in APC increased the OR 1.7 times (1.4–2.2), and 1.5 times (1.2–1.9) after adjustment for cardiovascular risk factors. Low APC levels were also associated with the number of coronary arteries affected and with the severity of coronary lesions (P
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
Myocardial Infarction
Coronary Artery Disease
Severity of Illness Index
Risk Factors
Internal medicine
Severity of illness
Odds Ratio
Humans
Medicine
Survivors
Myocardial infarction
Coronary atherosclerosis
business.industry
Anticoagulant
Age Factors
Case-control study
Hematology
Odds ratio
Middle Aged
medicine.disease
Surgery
Coronary arteries
medicine.anatomical_structure
Case-Control Studies
Cardiology
Female
business
Protein C
medicine.drug
Subjects
Details
- ISSN :
- 15387836 and 15387933
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Thrombosis and Haemostasis
- Accession number :
- edsair.doi.dedup.....521faaff93b8b7355f7f1301f61d314c