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Impact of betablockers on general and local outcome in patients hospitalized for lower extremity peripheral artery disease
- Source :
- Medicine
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Lower extremity peripheral artery disease (PAD) is one manifestation of atherosclerosis. Patients with PAD have an increased rate of mortality due to concurrent coronary artery disease and hypertension. Betablockers (BB) may, therefore, be prescribed, especially in case of heart failure. However, BB safety in PAD is controversial, because of presumed peripheral hemodynamic consequences of BB that could lead to worsening of symptoms in patients with PAD. In this context, we aimed to determine the impact of BB on all-cause and cardiovascular mortality and amputation rate at 1 year after hospitalization for PAD from the COPART Registry population. This is a prospective multicenter observational study collecting data from consecutive patients hospitalized for PAD in vascular medicine departments of 4 academic hospitals in France. Patients with, either claudication, critical limb ischemia or acute lower limb ischemia related to a documented PAD were included. We compared the outcomes of patients with BB versus those without BB in their prescription list at hospital discharge. The mean age of the study population was 70.9 years, predominantly composed of males (71%). Among the 1267 patients at admission, 28% were treated by BB for hypertension, prior myocardial infarction or heart failure. During their hospital stay, 40% underwent revascularization (including bypass surgery 29% and angioplasty 74%), 17% required an amputation, and 5% died. In a multivariate analysis, only prior myocardial infarction was found associated with BB prescription with an odds ratio (OR) of 3.11, P
- Subjects :
- Male
medicine.medical_treatment
Myocardial Infarction
030204 cardiovascular system & hematology
Coronary artery disease
0302 clinical medicine
Ischemia
Myocardial Revascularization
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Prospective cohort study
Aged, 80 and over
education.field_of_study
adult
General Medicine
Middle Aged
Hospitalization
Lower Extremity
Hypertension
Cardiology
Female
France
medicine.symptom
Research Article
medicine.medical_specialty
Adrenergic beta-Antagonists
Population
Observational Study
peripheral artery disease
Risk Assessment
Amputation, Surgical
Peripheral Arterial Disease
03 medical and health sciences
amputation
betablockers
Internal medicine
Angioplasty
medicine
Humans
education
Aged
Heart Failure
business.industry
Critical limb ischemia
Intermittent Claudication
Length of Stay
medicine.disease
mortality
Amputation
Claudication
business
Subjects
Details
- ISSN :
- 00257974
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....521b5ffbe6745f41a69b7f93e2e1a867