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Lidocaine Treatment of Painful Diabetic Neuropathy and Endogenous Opioid Peptides in Plasma
- Source :
- Scopus-Elsevier, Europe PubMed Central
- Publication Year :
- 1989
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1989.
-
Abstract
- Intravenous infusion of lidocaine has a pain-relieving effect in patients with painful diabetic neuropathy. We measured plasma beta-endorphin (beta-EP), dynorphin immunoreactivity (DYN), and met-enkephalin (MET) before and after lidocaine infusion in 8 patients with painful diabetic neuropathy and in 10 controls. The pretreatment level of beta-EP and DYN was identical in the two groups. After lidocaine, beta-EP increased in diabetic patients from 3.4 to 5.5 pmol/L (median) (p less than 0.02) and in controls from 3.4 to 5.0 pmol/L (p less than 0.02). The concentration of DYN was stable, and MET was undetectable before and after lidocaine. Lidocaine reduced symptoms and pain score in diabetic patients was uncorrelated with the changes in beta-EP. Intravenous lidocaine increased plasma beta-EP and diminished complaints in patients with painful diabetic neuropathy.
- Subjects :
- Adult
Male
Lidocaine
medicine.drug_class
Radioimmunoassay
Pain
Dynorphin
Dynorphins
Diabetic Neuropathies
Diabetes mellitus
Blood plasma
medicine
Humans
Opioid peptide
business.industry
Local anesthetic
beta-Endorphin
Middle Aged
medicine.disease
Anesthesiology and Pain Medicine
Peripheral neuropathy
Painful diabetic neuropathy
Anesthesia
Female
Endorphins
Neurology (clinical)
business
medicine.drug
Subjects
Details
- ISSN :
- 07498047
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- The Clinical Journal of Pain
- Accession number :
- edsair.doi.dedup.....52129d6bdd2a72d3b85bbbf3a979eeb9