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Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types
- Source :
- Data in Brief, Vol 36, Iss, Pp 107014-(2021), Data in Brief
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- In a population-based case control study of testicular germ cell tumors (TGCT), we reported a strong positive association between serum levels of Wolff's Group 1 (potentially estrogenic) polychlorinated biphenyl (PCBs) and risk of TGCT, and the observed associations were similar for both seminoma and non-seminoma. While the observed specific associations between TGCT and Wolff's Group 1 PCBs cannot be easily explained by bias or confounding, a question can still be asked, that is, could the relationship between PCBs and TGCT differ by age at diagnosis? PCBs tend to bioaccumulate, with more heavily chlorinated PCB congeners tending to have longer half-lives. Half-lives of PCB congeners were reported ranging from 4.6 years for PCB-28 to 41.0 years for PCB-156. The half-life for the heavy PCB congeners (17.8 years) was found to be approximately twice that for the light PCBs (9.6 years) in early studies. Therefore, the same PCB concentration measured in a 20-year-old vs. a 55-year-old is unlikely to represent the same lifetime PCB exposure or type of PCB exposure. In this analysis, we stratified the data by median age of diagnosis of TGCT and further stratified by histologic type of TGCT (seminoma vs non-seminoma) to explore if the risk of TGCT associated with PCB exposures differs by age.
- Subjects :
- Science (General)
Population
Computer applications to medicine. Medical informatics
Testicular Germ Cell Tumor
R858-859.7
Age at diagnosis
Physiology
Polychlorinated biphenyl
03 medical and health sciences
chemistry.chemical_compound
Q1-390
0302 clinical medicine
medicine
education
Endocrine disruptors
Data Article
030304 developmental biology
0303 health sciences
education.field_of_study
Multidisciplinary
business.industry
Confounding
Persistent organic pollutants
Case-control study
food and beverages
Seminoma
medicine.disease
Testicular germ cell
chemistry
Testicular germ cell tumor
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....51f503daded49764cf6fce2326041038