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Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
- Source :
- Brazilian Journal of Infectious Diseases, Vol 9, Iss 4, Pp 341-347, Brazilian Journal of Infectious Diseases, Volume: 9, Issue: 4, Pages: 341-347, Published: AUG 2005, Brazilian Journal of Infectious Diseases v.9 n.4 2005, Brazilian Journal of Infectious Diseases, Brazilian Society of Infectious Diseases (BSID), instacron:BSID
- Publisher :
- Elsevier
-
Abstract
- Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock syndrome and in dengue shock syndrome. The clinical features of DHF include plasma leakage, bleeding tendency and liver involvement. We studied the histopathological features of a fatal case of dengue-3 virus infection. The patient, a 63-year old male, presented with an acute onset of severe headache, myalgia and maculopapular rash. Tissue fragments (liver, spleen, lung, heart, kidney and lymph nodes) were collected for light microscopy studies and stained by standard methods. Histopathology revealed severe tissue damage, caused by intense hemorrhage, interstitial edema and inflammation. Some tissue sections were also processed with the immunoperoxidase reaction, which revealed the dengue viral antigen. Dengue-3 virus was isolated and identified with electron microscopy in a C6/36 cell culture inoculated with the patient's serum. Viral particles were detected in the infected cell culture.
- Subjects :
- Microbiology (medical)
myalgia
Male
medicine.medical_specialty
Pathology
lcsh:QR1-502
Spleen
dengue hemorrhagic fever
Virus
lcsh:Microbiology
Dengue fever
lcsh:Infectious and parasitic diseases
Fatal Outcome
Dengue virus serotype 3
immunoperoxidase
medicine
Maculopapular rash
Humans
lcsh:RC109-216
Severe Dengue
Immunoperoxidase
business.industry
Middle Aged
medicine.disease
Infectious Diseases
medicine.anatomical_structure
Microscopy, Electron, Scanning
Histopathology
Lymph
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 16784391
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....51ea543dca930e379cef11492c9666ed