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Verbal working memory and functional large-scale networks in schizophrenia
- Source :
- Dauvermann, M R, Moorhead, T W, Watson, A R, Duff, B, Romaniuk, L, Hall, J, Roberts, N, Lee, G L, Hughes, Z A, Brandon, N J, Whitcher, B, Blackwood, D H, Mcintosh, A M & Lawrie, S M 2017, ' Verbal working memory and functional large-scale networks in schizophrenia ', Psychiatry Research: Neuroimaging, vol. 270, pp. 86-96 . https://doi.org/10.1016/j.pscychresns.2017.10.004
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The aim of this study was to test whether bilinear and nonlinear effective connectivity (EC) measures of working memory fMRI data can differentiate between patients with schizophrenia (SZ) and healthy controls (HC). We applied bilinear and nonlinear Dynamic Causal Modeling (DCM) for the analysis of verbal working memory in 16 SZ and 21 HC. The connection strengths with nonlinear modulation between the dorsolateral prefrontal cortex (DLPFC) and the ventral tegmental area/substantia nigra (VTA/SN) were evaluated. We used Bayesian Model Selection at the group and family levels to compare the optimal bilinear and nonlinear models. Bayesian Model Averaging was used to assess the connection strengths with nonlinear modulation. The DCM analyses revealed that SZ and HC used different bilinear networks despite comparable behavioral performance. In addition, the connection strengths with nonlinear modulation between the DLPFC and the VTA/SN area showed differences between SZ and HC. The adoption of different functional networks in SZ and HC indicated neurobiological alterations underlying working memory performance, including different connection strengths with nonlinear modulation between the DLPFC and the VTA/SN area. These novel findings may increase our understanding of connectivity in working memory in schizophrenia.
- Subjects :
- Male
functional large-scale networks
altered effective connectivity
Bilinear interpolation
Developmental psychology
0302 clinical medicine
Neural Pathways
Causal model
medicine.diagnostic_test
prefrontal cortex neurons
Middle Aged
Magnetic Resonance Imaging
midbrain dopamine
Ventral tegmental area
Substantia Nigra
Psychiatry and Mental health
medicine.anatomical_structure
Memory, Short-Term
Schizophrenia
dopamine-glutamate interactions
Female
Schizophrenic Psychology
Psychology
Adult
Scale (ratio)
Neuroscience (miscellaneous)
ventral tegmental area
Prefrontal Cortex
dynamic causal-models
working memory
03 medical and health sciences
Young Adult
medicine
Humans
Radiology, Nuclear Medicine and imaging
magnetic-resonance spectroscopy
cognitive impairment
synaptic plasticity
Working memory
Functional Neuroimaging
Bayes Theorem
medicine.disease
functional magnetic resonance imaging
nonlinear dynamic causal modeling
030227 psychiatry
Dorsolateral prefrontal cortex
schizophrenia
Nonlinear Dynamics
Case-Control Studies
gain modulation
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dauvermann, M R, Moorhead, T W, Watson, A R, Duff, B, Romaniuk, L, Hall, J, Roberts, N, Lee, G L, Hughes, Z A, Brandon, N J, Whitcher, B, Blackwood, D H, Mcintosh, A M & Lawrie, S M 2017, ' Verbal working memory and functional large-scale networks in schizophrenia ', Psychiatry Research: Neuroimaging, vol. 270, pp. 86-96 . https://doi.org/10.1016/j.pscychresns.2017.10.004
- Accession number :
- edsair.doi.dedup.....51e7d0a39f9f0064ab1a04f3c7f7a567