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Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety
- Source :
- Bioorganicmedicinal chemistry letters. 21(6)
- Publication Year :
- 2010
-
Abstract
- A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays.
- Subjects :
- Stereochemistry
viruses
Hepatitis C virus
Clinical Biochemistry
Pharmaceutical Science
Hepacivirus
Viral Nonstructural Proteins
medicine.disease_cause
Benzothiadiazines
Virus Replication
Biochemistry
chemistry.chemical_compound
Drug Discovery
medicine
Moiety
Protease Inhibitors
Replicon
Molecular Biology
chemistry.chemical_classification
biology
Chemistry
Organic Chemistry
Quinoline
biochemical phenomena, metabolism, and nutrition
Enzyme
Enzyme inhibitor
Benzothiadiazine
biology.protein
Molecular Medicine
Bioisostere
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 21
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....51e6a260bf9d95965946bdcb5c353257