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Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome
- Source :
- Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 36(7)
- Publication Year :
- 2016
-
Abstract
- The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentrations in women with polycystic ovary syndrome (PCOS). Forty-nine women with PCOS, diagnosed according to Rotterdam criteria and 39 healthy women matched for body mass index (BMI) and age. Serum irisin and plasma FABP4 concentrations were measured in both groups. The association of irisin and FABP4 concentrations with metabolic parameters were also tested. Women with PCOS had significantly lower mean serum irisin concentrations than control subjects (158.5 ± 123.3 versus 222.9 ± 152.2 ng/ml, p 0.05). Concentrations of FABP4 in PCOS and control groups were not significantly different (10.5 ± 4.4 versus 10.9 ± 4.2 ng/ml, p 0.05). FABP4 concentrations were correlated with BMI, waist-hip ratio (WHR) and HOMA-IR (r = 0.57, p = 0.001; r = 0.26, p = 0.03; r = 0.26, p = 0.03, respectively). No associations between irisin and all the others parameters except serum levels of LH were found. Serum irisin concentrations of women with PCOS were lower compared to the controls. Moreover, there were no difference in plasma FABP4 concentrations between women with PCOS and controls.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Turkey
Statistics as Topic
030209 endocrinology & metabolism
Fatty Acid-Binding Proteins
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Insulin
In patient
business.industry
Waist-Hip Ratio
nutritional and metabolic diseases
Obstetrics and Gynecology
Luteinizing Hormone
Control subjects
Polycystic ovary
Fibronectins
030104 developmental biology
Endocrinology
Research Design
Female
Insulin Resistance
business
Body mass index
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 13646893
- Volume :
- 36
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
- Accession number :
- edsair.doi.dedup.....51e364ff4e2c8bdb67d8ab2d88493a38