492. Bioreducible Dendrimer Polymer-Mediated Human Relaxin Expression for Post-Infarct Cardiac Remodeling

After myocardial infarction (MI), the heart undergoes a series of structural changes, termed post-infarct cardiac remodeling, at the organ, cellular, and molecular levels. During decades, diverse efforts in experimental and clinical trials have been made to investigate promising cardio-protective strategies. In our previous work, the aggressive rescue for the central fibrotic lesion in left ventricle (LV) after MI is emerging as one of key therapeutic targets to overcome limited functional and prognostic improvements.