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Insulin-like Growth Factor 1 Differentially Affects Lithium Sensitivity of Lymphoblastoid Cell Lines from Lithium Responder and Non-responder Bipolar Disorder Patients
- Source :
- Journal of Molecular Neuroscience. 56:681-687
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Bipolar disorder (BD) is a chronic psychiatric illness with an unknown etiology. Lithium is considered the cornerstone in the management of BD, though about 50-60 % of patients do not respond sufficiently to chronic treatment. Insulin-like growth factor 1 (IGF1) has been identified as a candidate gene for BD susceptibility, and its low expression has been suggested as a putative biomarker for lithium unresponsiveness. In this study, we examined the in vitro effects of insulin-like growth factor 1 (IGF-1) on lithium sensitivity in lymphoblastoid cell lines (LCLs) from lithium responder (R) and non-responder (NR) bipolar patients. Moreover, we evaluated levels of microRNA let-7c, a small RNA predicted to target IGF1. We found that exogenous IGF-1 added to serum-free media increased lithium sensitivity selectively in LCLs from NR BD patients. However, no significant differences were observed when comparing let-7c expression in LCLs from R vs. NR BD patients. Our data support a key role for IGF-1 in lithium resistance/response in the treatment of bipolar disorder.
- Subjects :
- Candidate gene
medicine.medical_specialty
Bipolar Disorder
Lithium (medication)
medicine.medical_treatment
Lymphoblastoid cell lines (LCLs)
Drug Resistance
Lithium
Cell Line
Treatment of bipolar disorder
Insulin-like growth factor 1 (IGF-1)
Cellular and Molecular Neuroscience
Insulin-like growth factor
Internal medicine
microRNA
medicine
Humans
Lymphocytes
Bipolar disorder
Insulin-Like Growth Factor I
business.industry
Medicine (all)
Growth factor
Let-7c
Somatomedin C
Biomarkers
Female
MicroRNAs
General Medicine
medicine.disease
Endocrinology
Biomarker (medicine)
business
medicine.drug
Subjects
Details
- ISSN :
- 15591166 and 08958696
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Neuroscience
- Accession number :
- edsair.doi.dedup.....51d96f358f74f99e2b05f48dadef1fc3