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Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation
- Source :
- BioResearch open access, vol 4, iss 1, O'Connell, GD; Leach, JK; & Klineberg, EO. (2015). Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation.. BioResearch open access, 4(1), 431-445. doi: 10.1089/biores.2015.0034. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/93b909rd, BioResearch Open Access, BioResearch Open Access, Vol 4, Iss 1, Pp 431-445 (2015)
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- The intervertebral disc is a critical part of the intersegmental soft tissue of the spinal column, providing flexibility and mobility, while absorbing large complex loads. Spinal disease, including disc herniation and degeneration, may be a significant contributor to low back pain. Clinically, disc herniations are treated with both nonoperative and operative methods. Operative treatment for disc herniation includes removal of the herniated material when neural compression occurs. While this strategy may have short-term advantages over nonoperative methods, the remaining disc material is not addressed and surgery for mild degeneration may have limited long-term advantage over nonoperative methods. Furthermore, disc herniation and surgery significantly alter the mechanical function of the disc joint, which may contribute to progression of degeneration in surrounding tissues. We reviewed recent advances in tissue engineering and regenerative medicine strategies that may have a significant impact on disc herniation repair. Our review on tissue engineering strategies focuses on cell-based and inductive methods, each commonly combined with material-based approaches. An ideal clinically relevant biological repair strategy will significantly reduce pain and repair and restore flexibility and motion of the spine.
- Subjects :
- medicine.medical_specialty
Flexibility (anatomy)
lcsh:Medicine
regenerative medicine
disc mechanics
Bioengineering
Degeneration (medical)
Spinal disease
Regenerative medicine
General Biochemistry, Genetics and Molecular Biology
medicine
lcsh:QH301-705.5
Literature Review
low back pain
5.2 Cellular and gene therapies
5.3 Medical devices
business.industry
lcsh:R
Pain Research
Neurosciences
Soft tissue
Intervertebral disc
medicine.disease
Low back pain
Spinal column
Surgery
medicine.anatomical_structure
lcsh:Biology (General)
Musculoskeletal
disc degeneration
intervertebral disc
medicine.symptom
Development of treatments and therapeutic interventions
Chronic Pain
business
biomaterials
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BioResearch open access, vol 4, iss 1, O'Connell, GD; Leach, JK; & Klineberg, EO. (2015). Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation.. BioResearch open access, 4(1), 431-445. doi: 10.1089/biores.2015.0034. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/93b909rd, BioResearch Open Access, BioResearch Open Access, Vol 4, Iss 1, Pp 431-445 (2015)
- Accession number :
- edsair.doi.dedup.....51cf2811496ded5c6f90f05588dc8ae1