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Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 6259, p 6259 (2021)
- Publication Year :
- 2021
-
Abstract
- Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy-induced neurodegenerative and retinal disorders. Impairment of the barrier function triggers inflammatory events that worsen disease pathology. Studies have shown that AD patients also suffer from visual impairments. As an extension of the central nervous system, the retina has been suggested as a prominent site of AD pathology. This review highlights inflammation as a possible underlying mechanism of HHcy-induced barrier dysfunction and neurovascular injury in aging diseases accompanied by HHcy, focusing on AD.
- Subjects :
- 0301 basic medicine
Hyperhomocysteinemia
Retinal Disorder
genetic structures
QH301-705.5
Central nervous system
Inflammation
Review
Disease
Bioinformatics
Catalysis
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Central Nervous System Diseases
medicine
Animals
Humans
Biology (General)
Physical and Theoretical Chemistry
QD1-999
age-related macular degeneration
Molecular Biology
Homocysteine
Spectroscopy
Retina
business.industry
Organic Chemistry
Age Factors
General Medicine
Diabetic retinopathy
Macular degeneration
medicine.disease
eye diseases
Computer Science Applications
Chemistry
diabetic retinopathy
030104 developmental biology
medicine.anatomical_structure
medicine.symptom
business
Alzheimer’s disease
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....51cb3ffcaa97d4457d1275b012bed243