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IgA multiple myeloma coexistent with atypical adult T-cell leukemia
- Source :
- European journal of haematology. 38(5)
- Publication Year :
- 1987
-
Abstract
- We report a 65-yr-old male with adult T-cell leukemia (ATL) who developed multiple myeloma (MM) concomitantly. Skin lesions and peripheral leukocytosis were noted during the 5-yr observation period. There was abnormal lymphocytosis with indented or lobulated nuclei in the peripheral blood and in the bone marrow. The neoplastic cells reacted with monoclonal antibodies, OKT3, OKT4, OKIa1 and anti-Tac. His serum was positive for the antibodies to ATL-associated antigens. Human T-cell leukemia virus (HTLV) proviral DNA was detected in the leukemic cells. Thus, a diagnosis of ATL was made. There was IgA (k) paraprotein in his serum, and Bence-Jones protein (k) in urine samples. Fine needle aspiration revealed pathologic flaming plasma cells. Multiple osteolytic lesions appeared on his skull 5 yr after the initial examination. Thus, a diagnosis of MM concomitant with ATL was made.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
Male
Pathology
medicine.medical_specialty
Lymphocytosis
medicine.drug_class
Chronic lymphocytic leukemia
T-Lymphocytes
T-cell leukemia
Monoclonal antibody
Deltaretrovirus
immune system diseases
hemic and lymphatic diseases
Medicine
Humans
Leukocytosis
Multiple myeloma
Aged
Leukemia
business.industry
Hematology
General Medicine
medicine.disease
Immunoglobulin A
Neoplasm Proteins
medicine.anatomical_structure
Immunology
DNA, Viral
Bone marrow
medicine.symptom
business
Multiple Myeloma
Follow-Up Studies
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 38
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of haematology
- Accession number :
- edsair.doi.dedup.....51c834a08181e96e654981def822ce6e